Aprotinin

Kallikrein

Papain

Pancreatic Elastase

Chymotrypsin

Pepsin

Thrombin

Trypsin

Urokinase

Glucanase

Human Urokinase


Synonyms: Urokinase, Urokinase type plasminogen activator, Urinary type plasminogen activitor, uPA, UK, hUK

CAS No.: 9039-53-6

EC No.: 3.4.21.73

Urokinase is a thrombolytic agent that actives plasminogen. It is a white or almost white, amorphous powder prepared from human urine. Urokinase consists of the serine protease domain, the kringle domain and the growth factor domain.
  

Jiagen Biotechnologies supplies quality Urokinase of various specifications. To place an order or for more information, please contact us at sales@jiagen.com.

References:
1. Andreasen PA, Kioller L, Christensen L, Duffy MJ 1997: The urokinase-type plasminogen activator system in cancer metastasis: a review, Int J Cancer 72(1): 1-22.
2. Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA 2001: Urokinase receptors promote beta 1 integrin function though interactions with integrin alpha 3 beta 1, Mol Biol Cell 12(10): 2975-86.
3. John Romer, Leif R Lund, Jens Eriksen, Charles Pyke, Peter Kristensen, Keld Dano 1994: The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds, Journal of Investigative Dermatology 102: 519-22.
4. Stump DC, Stassen JM, Demarsin E, Collen D 1987: Comparative thrombolytic properties of single-chain forms of urokinase-type plasminogen activator, Blood 69(2):592-6.
5. Husain SS, Gurewich V, Lipinski B 1983: Purification and partial characterization of a single-chain high-molecular-weight form from human urine, Arch Biochem Biophys 220(1): 31-8.
6. Toki N, Sumi H 1982: Urinary trypsin inhibitor and urokinase activities in renal diseases, Acta Haematol 67(2): 109-13.
7. Mutoh S, Maki M, Takahashi S, Abe T 1982: Effect of combined use of dextran sulfate and urokinase in cases of preeclampsia-behavior of blood coagulaiton-fibrinolysis and inhibitor systems, Nippon Sanka Fujinka Gakkai Zasshi 34(9): 1519-27.
8. Booyse FM, Osikowicz G, Feder S, Scheinbuks J 1984: Isolation and characterization of a urokinase-type plasminogen activator (Mr = 54,000) from cultured human endothelial cells indistinguishable from urinary urokinase, J Biol Chem 259(11): 7198-205.
9. Nobuhara M, Sakamaki M, Ohnishi H, Suzuki Y 1981: A comparative study of high molecular weight urokinase and low molecular weight urokinase, J Biochem 90(1): 225-32.
10. Ueno T, Kobayashi N, Maekawa T 1979: Studies on metabolism of urokinase and mechanism of thrombolysis by urokinase, Thromb Haemost 42(3): 885-94.
11. Gurewich V 1987: Experiences with pro-urokinase and potentiation of its fibrinolytic effect by urokinase and tissue plasminogen activator, J Am Coll Cardiol 10 (5 suppl B): 16B-21B.
12. Mutoh S, Kobayashi M, Hirata J, Itoh N, Maki M, Komatsu Y, Yoshida A, Sasa H, Kuroda K, Kikuchi Y, et al 1992: Urinary coagulation-fibrinolysis, kallikrein-kinin systems and kininase in cases of preclampsia, Agents Actions Suppl 38(Pt2): 330-41.