Human Chorionic Gonadotropin (HCG)
Synonyms: Human Chorionic Gonadotrophin, Gonadotropinum chorionicum, Choriogonin, HCG
CAS No.: 9002-61-3
Human Chorionic Gonadotropin is a white to almost white powder extracted from the urine of pregnant women. It is a gonad-stimulating hormone, a placental glycoprotein with luteinizing activity. HCG consists of α (alpha) subunit and β (beta) subunit. The α (alpha) subunit is identical to that of Follicle Stimulating Hormone (FSH), Luteinizing hormone (LH) and Thyroid Stimulating Hormone (TSH), while the β (beta) subunit is unique to HCG.
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References:
1. Usui T, Ishibe T, Matsumoto S 1987: HCG and HMG treatment of male infertility with pituitary problems, Urology 29(1): 50-3.
2. Birken S, Chen Y, Gawinowicz MA, Lustbader JW, Pollak S, Agosto G, Buck R, O'Connor J 1993: Separation of nicked human chorionic gonadotropin (hCG), intact hCG, and hCG beta fragment from standard reference, Endocrinology 133(3): 1390-7.
3. Birken S, Kolks MA, Amr S, Nisula B, Puett D 1987: Structural and functional studies of the tryptic core of the human chorionic gonadotropin beta-subunit, Endocrinology 121(2): 657-66.
4. Frank L Greenway, George A. Bray 1977: Human chorionic gonadotropin (HCG) in the treatment of obesity, West J Med 127: 461-3.